![]() ![]() ![]() A general prediction of evolutionary genetics is that gene regulation should evolve largely through changes in independent cis-regulatory “modules” that segregate developmental roles while minimizing deleterious pleiotropic side effects of mutation ( 10, 11). Population genetic scans and comparative gene expression studies suggest that cis-regulatory differences underlie adaptive variation of red color patterns, and recent work has sought to characterize the specific noncoding regions around optix responsible for this ( Fig. Incredibly, red color pattern diversity in the genus Heliconius is largely controlled by divergent expression of a single gene, optix, making Heliconius an important case study of how variation at a single major effect locus can drive adaptation of a complex trait both within and between species ( Fig. Approximately 10 to 15 MYA, Heliconius spread across Central and South America, evolving red, black, and yellow aposematic wing patterns to warn predators of their toxicity ( 6). These butterflies are one of the defining examples of Müllerian mimicry, where local populations have evolved warning coloration to mimic other local toxic butterfly and moth species ( 4, 5). Neotropical Heliconius butterflies are a classic example of an adaptive radiation driven by few genes of large effect ( 1– 3). ![]() Our results support a model of color pattern evolution in Heliconius where changes to ancient, multifunctional cis-regulatory elements underlie adaptive radiation. Remarkably, we found orthologous cis-regulatory elements associate with wing pattern convergence of distantly related comimics, suggesting that parallel coevolution of ancestral elements facilitated pattern mimicry. We were surprised to find that the cis-regulatory architecture of optix is characterized by pleiotropy and regulatory fragility, where deletion of individual cis-regulatory elements has broad effects on both color pattern and wing vein development. Here we combine chromatin assays, DNA sequence associations, and genome editing to functionally characterize 5 cis-regulatory elements of the color pattern gene optix. Association studies have linked color pattern variation to a handful of noncoding regions, yet the presumptive cis-regulatory elements (CREs) that control color patterning remain unknown. Color pattern mimicry in Heliconius butterflies is a classic case study of complex trait adaptation via selection on a few large effect genes. ![]()
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![]() ![]() You’ll love the deep discounts on everything from your favorite bags, luggage, accessories, and home goods. The Vera Bradley Outlet Sale offers huge discounts on a wide range of Vera Bradley products. Amazing Discounts on Vera Bradley Products Here’s why you’ll love the Vera Bradley Annual Outlet Sale. However, until you’ve been to the annual Vera Bradley Outlet Sale, you haven’t seen it all. If you’ve ever been inside a Vera Bradley retail location, you’ve seen the colorful, fun prints, the understated microfiber quilted bags, the floral umbrellas, and gorgeous beach towels. The Vera Bradley Outlet SaleĮvery year, Indiana-grown purse company, Vera Bradley compiles all of their extra inventory and specialty items and sets them out on rows and rows of tables at the Allen County War Memorial Coliseum in Fort Wayne (think HUGE convention center) and opens the doors to the public for scheduled shopping times.Īt the Vera Bradley Annual Outlet Sale, these items are priced to sell at 40-70% off retail! 7 Things You’ll Love About the Vera Bradley Annual Outlet Sale? It takes place at the Allen County War Memorial Coliseum in Fort Wayne at 4000 Parnell Ave, Fort Wayne, Indiana. ![]() Mark your calendar, the annual Outlet Sale is June 14 – 18, 2023. Attendees have such a great time that they’ve hijacked the Vegas motto and changed it to, “What happens at the Vera Bradley Sale, stays at the Vera Bradley Sale.” When is the Vera Bradley Outlet Sale? Maybe you’ve heard all of the stories of (mostly) women taking over the city by the minivan full, booking a weekend in the hotels, creating special “team” or group shirts for the occasion, spending entire paychecks, and having a really good time. I know there are a LOT of things to do in Fort Wayne, but the Vera Bradley Sale is top of the list. Visit follow to learn more.The very first time I visited the annual Vera Bradley Annual Outlet Sale in Fort Wayne, Indiana, I was giddy. Miller, the brand is known for its innovative designs, iconic patterns, and brilliant colors that inspire and connect women unlike any other brand in the global marketplace. Founded in 1982 by friends Barbara Bradley Baekgaard and Patricia R. ![]() Vera Bradley, based in Fort Wayne, Indiana, is a leading designer of women’s handbags, luggage and other travel items, fashion and home accessories, and unique gifts. Travel, hotel, tourism and group tour information is available at ABOUT VERA BRADLEY According to Visit Fort Wayne, the Fort Wayne/Allen County Convention and Visitors Bureau, each year the Sale generates more than $5 million in tourism revenue for the Fort Wayne community.įor additional Sale information and updates, visit and follow on Instagram and Facebook. Past Vera Bradley Annual Outlet Sales have consistently attracted 40,000+ shoppers, representing all 50 states and several countries. Shoppers can donate $20 to access a “fast pass” lane to expedite their checkout experience, enter for the chance to win the Foundation’s “Quilt with a Cause,” round up their purchase to the nearest dollar at checkout and shop limited-edition Foundation apparel. Vera Bradley will invite customers to join the Company in supporting the Vera Bradley Foundation for Breast Cancer (the “Foundation”) when they visit the Sale. Wednesday, June 14 through Friday, June 16Ĥ Shopping Sessions Daily Tickets Required The Sale will be open for public shopping (no ticket required) on June 17 and June 18. The first three days of the Sale offer multiple ticketed sessions for shoppers to take advantage of the best selection of Vera Bradley handbags, travel items, accessories, stationery and luggage in a variety of current and retired patterns, along with bracelets and other items from VRA-owned lifestyle brand Pura Vida-all discounted up to 70% off MSRP. ![]() Customers who purchase tickets after April 3 will receive $10 off their Sale purchase of $100 or more. “Early Bird” shoppers who purchase Sale tickets by April 3 will receive a special promotional offer of $25 off a purchase of $150 or more, redeemable at the Sale. Tickets are $6 each (plus Ticketmaster fees) and are required to shop the Sale from June 14 to June 16. Sale admission tickets will be available for purchase today beginning at 10 am EST at, authorized Ticketmaster locations and the Allen County War Memorial Coliseum Ticket Office. Back by popular demand following a three-year hiatus due to the COVID-19 pandemic, the Sale will be hosted at the Allen County War Memorial Coliseum in Fort Wayne, Ind. (NASDAQ: VRA) and its iconic American bag and luggage lifestyle brand, Vera Bradley, today announced the launch of ticket sales for the 2023 Vera Bradley Annual Outlet Sale (the “Sale”). FORT WAYNE, Ind., Ma(GLOBE NEWSWIRE) - Vera Bradley, Inc. ![]() ![]() ![]() Best of all, you can get tech support from the Microsoft Answer Desk experts, by phone or chat - at no extra charge. In addition, Office 365 subscribers will get 60 minutes of Skype calling per month so you can stay in touch with friends and colleagues around the globe. 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